Healthcare IT Startups funded by Y Combinator (YC) 2026

Ritivel is an AI-native workspace for regulatory and medical writing teams at life sciences companies. Our AI agents draft CTDs, CSRs, INDs, and BLAs in minutes instead of weeks, helping drugs reach patients faster. Every month a drug is delayed from reaching the market costs pharma companies ~$45M in lost revenue and more importantly, delays treatment for thousands of patients who need it. Yet regulatory teams are stuck in a painful, months-long process: synthesizing thousands of pages of clinical data, hunting through SharePoint folders for the right documents, chasing colleagues for missing inputs, and manually drafting submissions. Ritivel deploys AI agents that transform how regulatory teams work. Our agents generate comprehensive first drafts directly in Microsoft Word, following FDA formatting requirements and pulling from your existing clinical data and prior submissions. Every data point includes citations linked back to the original source, so reviewers can verify with one click. Connected to SharePoint and Veeva, our agents automatically source the right documents. Integrated with Outlook, they handle reminder emails and follow-ups automatically. We're engineers who previously built AI copilots at Microsoft Research. After 50+ conversations with pharma professionals, we discovered the critical bottleneck in regulatory submissions and built Ritivel to solve it.

The universal AI front desk for healthcare: plugs into any practice management system (cloud-based or on-premise) and automates all patient workflows: scheduling, cancellations, payment plans, insurance checks, reminders, intake, and follow-ups.

Kaigo Health provides an AI-powered outpatient care management platform that automates and scales remote care management for Medicare patients including post-discharge followups, ongoing check-ins, and monitoring. Using phone calls as an age-friendly interface, we aggregate patient responses, voice biomarkers, and remote patient monitoring data for powerful preventative and proactive healthcare.

LunaBill is building AI Voice callers for healthcare billing teams. Insurance claim follow-up calls account for the 80% of the daily workload of a healthcare billing team, with each call averaging 30 minutes. Since our launch in July we are now at $764K in contracted ARR, of which $428K is live revenue and the rest will go live by January 2026. Our customers see a 10x increase in claims followed up per biller in the first week and we have converted 100% of pilots to paying customers. We have automated 50,000+ calls and signed partnerships with top healthcare leaders like UC health systems, Mayo, Experian Health and more. The founders have known each other for over a year. Suhail is a 2x founder, with 3+ years of experience building in healthcare including operating a medical billing company with 200+ healthcare clients. David founded Skiesoft, Taiwan’s biggest healthcare AI scribe company, used by 120k+ healthcare professionals. He also worked as a data scientist at UCSF, building models to audit medical-coding accuracy. Yash was a researcher at various hospital systems including Mayo Clinic.

When enterprise agents fail in production, the conditions that caused the failure are critical: user state, data, tool calls, and context. Without a way to recreate these conditions, teams can't fix what broke. Playgent provides infrastructure to create high-fidelity sandbox environments for AI agents. Our environments come packaged as a single MCP url where tool calls are mocked, authentication is abstracted away, and test data can be initialized via natural language or JSON specifications. Teams can use Playgent to reproduce production failures in safe, scoped environments that accurately reconstruct state. Finally, export runs as OTel traces from Playgent's environment to plug directly into your observability tools or RL pipelines.

𝐖𝐡𝐲 𝐰𝐞 𝐛𝐮𝐢𝐥𝐭 𝐭𝐡𝐢𝐬: I (Angel) have had three knee surgeries since my mid-teens and was billed more than $250K for care that should have cost a fraction of that. Fighting those inflated charges was so painful that we set out to build a consumer-facing AI agent to do it for others. In less than five months, we helped sixty patients erase or reduce over $300K from their medical bills. This inspired us to fix the problem farther upstream: stopping bad payments before the patient ever sees a bill. So we launched payment integrity, machine-learning models that audit every medical claim for self-insured employers and health plans in real time. 𝐓𝐡𝐞 𝐏𝐫𝐨𝐛𝐥𝐞𝐦: • Self-insured employers waste $60 B+ each year on claims that never should have been paid. Healthcare is the 2nd largest company expense after payroll. • Manual audits are slow and partial: Reviewers focus only on high-dollar claims, letting millions more slip through unnoticed. • Existing audit software is static: Decades-old rule engines can’t keep pace with evolving codes, contracts, or billing tactics. • Incentives are misaligned: Third-party administrators are paid to process claims, not to police them, so accuracy checks are minimal. 𝐎𝐮𝐫 𝐒𝐨𝐥𝐮𝐭𝐢𝐨𝐧: Our models audit medical claims before and after payments have been issued. We catch nuanced billing, coding, and contract errors to save 3-7% on annual claims spend. We work with self-insured employers and health plans. 𝐀𝐛𝐨𝐮𝐭 𝐔𝐬: Angel Onuoha (CEO) and Ahmad Shehu (CTO) have worked together for 4 years. Before Avelis Health they built Zuvy, a Lagos-based fintech company that provided invoice factoring to small businesses. Zuvy was acquired by The BAS Group in 2025.

Locata is an AI referral management platform for Primary Care. We deploy AI agents to automate every step of the referral process that back-office staff face daily, from submitting prior authorizations to broadcasting updates and following up with patients. This frees up staff to focus on patient care. Primary care back-offices are severely understaffed and overburdened by administrative work associated with referrals. Additionally, patients suffer navigating the complex referral process, which can have disastrous health effects if they don’t get the care they need. These factors point to a glaring gap in the system—where out of over 100 million specialist referrals issued annually in the US, only half are actually completed. Locata is tackling this problem head-on, saving administrative staff hours each week and ensuring that the referral process goes as smoothly as possible for patients and their providers. Alejandro and Josh met at Stanford where they graduated with BS degrees in Computer Science. Alejandro was a senior software engineer at Meta’s Reality Labs where he led development of several AI features for wearable products and prior to that conducted AI research at Stanford Medicine. Josh graduated with a masters in Computer Science, specializing in AI, before working as a software engineer at Google where he developed AI products that served over 1 billion users. Within two weeks of building our product, we signed a major regional health center and have saved them over 100 hours of work in our first month live.

Parachute helps hospitals adopt AI safely and at scale. We vet AI tools that fill clinical gaps, run state-of-the-art evaluations, monitor every model for drift and compliance, and lock every decision in an immutable audit trail.

Phases uses AI to automate clinical trial operations, starting with patient recruitment. Our agent scans medical records and conducts human-like voice interviews to assess patient eligibility for clinical trials. Our vision is to run the entire clinical trial back-office with agents, getting drugs to market at a fraction of the time and cost it takes today.

America is facing an addiction and mental health crisis. We're building a suite of AI agents to automate away the tasks that occupy half of the time and resources of behavioral health clinics—documentation, compliance, audits, and more. We save time, money, and mental bandwidth so that clinicians can stop chasing insurance reimbursements and go back to saving lives.

Trapeze empowers doctors to answer patient calls 24/7 with our voice agents clones of their best call center reps and receptionists. In the past 3 months, we’ve onboarded 140+ doctors nationwide serving 1,000,000+ patients. We're building the AI-native Zocdoc to create the standard for how patients and providers find each other. Follow along on the BTS of our journey: https://www.tiktok.com/t/ZTjQyxEQx/

Aegis is the all-in-one platform that helps healthcare providers recover lost revenue by automating insurance denial appeals—from intake to resolution. Built for billing teams, healthcare providers and hospitals.

Adentris is an AI compliance copilot for hospitals and clinics. We are like Grammarly for doctors, finding and fixing mistakes that lead to denied insurance claims or patient lawsuits. The industry today spends $40B doing this manually.

Paratus Health is the AI operations layer for outpatient clinics. We build autonomous agents that don’t just assist staff - they replace them, fully handling front desk calls, patient intake, insurance verification, documentation, and billing prep. Everything is deeply integrated into EHRs like Epic and Athena, eliminating the need for fragmented tools and manual work. No toggling between systems. No busywork. Just one intelligent system running your clinical operations - faster, smarter, and more profitably than ever before.

Harbera helps clinic keep their doctors credentialed and compliant. Our AI software continuously monitors and proactively helps admin teams re-credential doctors, preventing denied claims, disruptions in patient care, and lost revenue caused by doctors falling out-of-network.

Amby Health automates billing and quality reviews for ambulance agencies (EMS), replacing large back-office teams with AI. We analyze patient reports in seconds—not months—accurately coding claims and identifying liability and care risks while eliminating costly, error-prone manual processes.

HealthKey helps doctors offices generate more revenue by finding eligible patients for their clinical trials. We match at-risk patients with cutting-edge treatments, ultimately getting patients access to potentially life-changing treatments faster. Big Pharma pays a lot of money to clinics for each patient they enroll, but finding patients who qualify is an entirely manual process today. We use AI to prescreen doctors’ existing patients against Clinical Trials’ eligibility criteria, making enrollment fast and easy.

We’re Toothy.ai. We’re building AI agents for dental practices that handle everything related to patient insurance. The average dental clinic spends over 160 hours a month on insurance tasks like verifying patient policies, billing, and claims processing. Our AI agents automate this entire workflow—including making insurance calls with voice AI—saving clinics time, reducing costs, and ensuring faster reimbursements.

Careforce builds AI Workers for healthcare orgs to take on coordination burden from staff and reduce time of care by autonomously identifying and outreaching patients (through phone, text, email, & mail) to schedule visits, book screenings, complete pre-post, and onboard. These agents require no integration, can navigate all tools, speak 29 languages, come with 50+ outreach scripts and have a remarkable 80% conversation-to-booking closing rate.

Durate helps physician groups, clinics, and hospitals eliminate coverage gaps and create personalized schedules. Our platform auto-syncs with existing systems and uses smart automation to build optimized physician schedules in seconds.

The main document in a clinical trial is the study protocol. At large companies, floors of people use the protocol to create the study data collection forms, clinical database design, error checks, analysis code, and data transformation mappings. We use AI to automate the process of creating everything from the protocol, saving not only spend on headcount but also months of time which can translate to up to $27M in direct costs + lost revenue saved for a single phase 3 trial.

Syntra automates chart review, claim review, and claim entry with AI. Our specialty-specific AI agents understand the clinical and payer nuances needed to run your RCM function autonomously. Syntra powers hundreds of specialty practices nationwide and processes over $1B in medical claim charges every year.

Planbase has everything health clinics need to manage their team in one place: capacity planning, employee scheduling, credentialing and payroll.

Dodo develops AI employees for specialty clinics, starting with veterinarians, fine-tuned on industry-specific knowledge and trained on protocols taken directly from employee manuals and playbooks, which often span multiple binders. Clinics hire Dodo's labor-as-a-software to handle front and back-office tasks, enabling clinics to provide 24/7 service. Dodo answers calls, sends medical records, and refills prescriptions—fully autonomously, with no human in the loop.

Sage is a HIPAA compliant, AI-native communication platform that makes home care agency client-intake handling smarter, faster, and more reliable. Teams that use Sage can save over 100 minutes of busywork per prospect, freeing up their teams to manage a larger, faster growing business.

Pharos automates hospital quality reporting, saving millions in labour costs and helping to prevent avoidable patient harm. Today, clinicians spend thousands of hours manually pulling complex facts out of medical records for mandatory reporting and quality improvement. Our AI pulls those facts out of unstructured medical records automatically. We automate reporting and show staff where avoidable patient harm is happening.

Sample transforms healthcare operations from a burden into a competitive advantage. Our users build copilots in Sample to support processes like patient intake and reimbursement. These copilots don't just speed up work – they capture valuable ground-truth data that make our models smarter over time. We work with leading national providers, already have data from 76% of US oncology clinics, and our network is rapidly expanding across the nation.

At Brighterway, we use AI to speed up the medical record review process in the Workers' Compensation Industry. Physicians and claims handlers spend hours reviewing thousands of pages of medical documents– our technology highlights the information that is most relevant to a doctor's specialty or a given injury, streamlining their review process and saving them time. Brighterway structures and deduplicates disorganized medical records (PDFs) and extracts the content that is medically relevant and related to a given claim, so they can focus on what matters most.

All-in-one RTM platform designed for physical therapy and powered by AI

Clarion is building the most advanced AI communication layer for healthcare. Our AI agents handle the overwhelming volume of calls and messages that clinics face daily—from scheduling to billing to prescription refills—freeing staff to focus on patient care. We're an in-person company based in New York. Today, clinics miss 30-40% of inbound calls due to staffing shortages. We're solving this by automating complex workflows end-to-end, already serving tens of thousands of patients monthly across virtual care companies, health systems, and a $5B health insurance company. We've raised $5.4M from Accel, Y Combinator, Sequoia (scout), and healthcare founders from Ophelia, Medallion, and Counsel Health. Our founders bring both clinical and technical expertise—our CEO Ryan is a Stanford/Harvard-trained physician who was on the founding teams of Two Chairs and Ophelia, while our CTO Jeffrey built voice AI at Amazon Alexa and led AI/ML teams at Salesforce. Join us as we transform healthcare communication—creating a future where patients get faster resolutions and providers reclaim time for what matters most.

At Arini, we’re building the operating system for dental groups. Phones are the backbone of dental operations — 80% of appointments are still booked over the phone — yet practices miss 20–30% of inbound calls. That’s millions in lost revenue every month. Patient engagement is the biggest bottleneck to growth in dentistry, and we’ve built the most comprehensive AI-powered patient engagement suite in the industry. Arini manages calls, texts, and bookings. We’re going after a $220B, overlooked industry that still runs on legacy systems and outdated workflows. Arini is bringing AI to every part of the dental stack.

Penciled (W24) is an AI front office assistant for physical therapy. Penciled's AI assistant schedules out plans of care, sends reminders and processes last-minute cancellations, and fills openings with an automated waitlist. Penciled books thousands of appointments for physical therapists each month and integrates directly into EHRs like WebPT.

We build AI agents that automate healthcare admin workflows. Our agents navigate legacy hospital software like humans (using mouse and keyboard) and automate end-to-end workflows (starting with medical coding), freeing medical professionals from manual tasks.

Andy is AI software that completes documentation for nurses doing home visits. Our software saves $8B a year; Tiantian was previously a PM at Google’s healthcare business and Max was a staff engineer on the health team at Apple. Andy benefits nurses and the agencies that employ them. Agencies that use Andy see up to 45% more detailed charts, 2x greater nurse productivity, and timely submission (no more billing delays!) With Andy, clinicians get their evenings back. Home health is the fastest growing segment of healthcare, doubling to $251B by 2031. Combined with recent nursing shortages and burnout, we’re seeing not just urgency, but excitement and joy, around adopting AI for home health.

InQuery is a fully-automated medical record review platform that indexes, labels, and summarizes patient medical records so that physicians and attorneys can understand patient journeys at a glance. Our proprietary technology reasons about each record to surface key insights that could make or break your medical legal case.

Fortuna is a one-stop solution that helps consumers navigate Medicaid end-to-end from eligibility and enrollment to renewing coverage. Our platform creates value as the middleware layer for the $800B Medicaid ecosystem.

Cair Health empowers billing companies, care management platforms, EHRs, offshore BPOs, provider groups, and specialty pharmacies with AI-driven RCM solutions. Our suite of AI Agents helps RCM teams streamline operations, reduce manual costs, and improve consistency—while maintaining full control over core workflows. Cair is trusted by 100+ practices across the country — including iconic VC-backed digital health startups, leading specialty EHRs, and some of the largest billing companies and BPOs Backed by Y Combinator, Foundation Capital, Soma Capital, Translink Capital & many others..

Wattson Health’s AI agents connect with customers over the phone and SMS. Give us your busiest tasks and we’ll train our agents to take them off your hands.

Medical practices struggle with front desk shortages and nonstop admin work—ringing phones, scheduling mishaps, intake errors, and billing headaches. The result? Overworked staff and less time for patient care. Decoda Health’s AI platform takes over 80% of these tedious tasks, handling calls, scheduling, and payments while alerting staff only when necessary. By reducing chaos and streamlining operations, teams can focus on what truly matters—providing exceptional patient care.

We use generative AI to call insurance on behalf of healthcare clinics. We save clinics up to 40 hours of calls every week over existing outsourced human solutions. Compared to the existing solutions for benefits verifications: - We're faster -- by default, we have a turnaround of 24 hours compared to typically a 3 day turnaround for competitors - We can reach more payors -- as long as they have a phone line, we can support calling them for benefits. There's quite a few payors in both medical and dental (e.g. Seledent) that have yet to offer a digital retrieval of benefits - We're reliable and consistent -- there is no person-to-person variation or question skipping when it comes to working with software

Sohar Health is an AI-driven front-end RCM solution that transforms insurance verification processes for healthcare providers, enabling faster patient conversions and reducing administrative workloads. With a 95% automation rate, our API-first platform seamlessly integrates into existing workflows to provide real-time claim accuracy and eligibility checks. Key performance metrics showcase the power of our technology: Median latency of just 6 seconds, ensuring real-time eligibility; over 90% of checks returned within 30 seconds for increased patient conversion; 96% accuracy in identifying and verifying benefits details; Industry-leading 99% accuracy for eligibility determination; >90% carve-out detection rate, mitigating surprise billing risks; a 60% success rate with our Insurance Discovery API, helping identify coverage for self-pay patients. Our customers include outpatient clinics, specialty practices, and digital health platforms looking to streamline front-end claim management. By reducing errors and maximizing clean claim submissions, Sohar Health empowers healthcare organizations to convert and retain more patients, reduce operating costs, and increase their top-line revenue.

Healthtech-1 automates repetitive processes for healthcare systems. We’re starting with the world’s most famous: the NHS. We’re already live in over 1,400+ primary care practices. Based out of Raj's parents' Primary Care practice the Healthtech 1 team are systematically digitising the repetitive processes they experience everyday, saving thousands of hours of staff time. Why now? The UK's National Health Service (NHS) delivers free healthcare in 590 million patient contacts every year. Post-pandemic, Britain's most treasured institution is in crisis. Patient satisfaction is at 25 year low and 1/7 staff are applying for Non-NHS jobs fuelling an 11% recruitment gap. By digitising the 100s of repetitive processes in healthcare, Healthtech 1 will reverse the trend, and produce the world's most productive health care system.

At Latent, we're building medical language models to tackle the trillions of operational overhead weighing down healthcare. Our flagship product streamlines authorizations for life-saving drugs by analyzing EHR records and surfacing the most relevant data. We've built our product and signed enterprise contracts with some of the largest health systems in the US.

Preventing revenue leakage in health systems using AI

Our AI browser assistant automates insurance tasks like verifying benefits, submitting prior auths, checking claim statuses, and more across all payer portals, directly from the clinic's EHR. It does exactly what the admin team is doing today, just helps them do it 10x faster and as thoroughly as a seasoned teammate.

Sanvivo builds a multisided platform to enable customers to order medications, get pharmaceutical advice, and book health services at local pharmacies in Europe. Just like Shopify for pharmacies. Sanvivo gives pharmacies software to take, fill and schedule delivery for online orders. We also bring instant demand through integrations with 3rd party consumer delivery companies. Almost all pharmacies in Europe are, by law, local 1-person businesses. And they are not ready for online orders. Regulatory changes require pharmacies to take and fill e-prescriptions (roll-out Jan-23), but many have no way to do this online today. Sanvivo uses technology to give local pharmacies digital superpowers, enabling them to combine fast supply and high-quality consultation with state of the are e-commerce solutions.

We empower clinicians with our AI platform for developing differential diagnoses and drafting clinical plans.

KemNet supplies pharmacies with premium reformulations of popular drugs that are more useful for specific groups of patients. For example, more than 30 pharmacies rely on KemNet to supply reformulated products for erectile dysfunction that work up to 8 times faster than alternatives. In addition to sexual function, products reformulated for novel drug delivery and supplied on KemNet include medications for hair growth, pain, weight loss and women's health.

Entvin is building AI agents specifically designed to support regulatory teams in the life sciences industry. Our platform leverages AI to streamline workflows, automate complex tasks, and enhance efficiency throughout the regulatory process. By focusing on the unique needs of regulatory teams, we help companies navigate compliance, accelerate approvals, and reduce operational bottlenecks, all while ensuring data security and confidentiality.

Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.